General Toxicity Notes
Blood levels most often the best guide to therapy. Half-life may be prolonged in heart failure or with reduced hepatic blood flow.
Half-Life (Normalesrd) Hours
4.4-8/4-14
Plasma Protein Binding %
80-88
Volume Of Distribution L/Kg
1.5-3.9
Dose For Normal Renal Function
300-600 mg q8-12h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
75% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,monitor serum concentration, [D]
References
Bellet S, Roman LR, Boza A. Relation between serum quinidine levels and renal function. Studies in normal subjects and patients with congestive failure and renal insufficiency. Am J Cardiol. 1971; 27: 368-71. [PMID: 5572580] / Kessler KM, Perez GO. Decreased quinidine plasma protein binding during hemodialysis. Clin Pharmacol Ther. 1981; 30: 121-6. [PMID: 7237891] / Ochs HR, Greenblatt DJ, Woo E. Clinical pharmacokinetics of quinidine. Clin Pharmacokinet. 1980; 5: 150-68. [PMID: 6988137]
Toxicity Notes
Increased plasma levels of digoxin and digitoxin in ESRD. Excretion enhanced in acid urine. Hemodialysis useful in poisoning.