General Toxicity Notes
Blood levels most often the best guide to therapy. Half-life may be prolonged in heart failure or with reduced hepatic blood flow.
Half-Life (Normalesrd) Hours
2/3
Plasma Protein Binding %
95
Volume Of Distribution L/Kg
>5.0
Dose For Normal Renal Function
200-300 mg q8h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, titrate, [D]
References
Pieniaszek HJ Jr, McEntegart CM, Mayersohn M, Michael UF. Moricizine pharmacokinetics in renal insufficiency: reevaluation of elimination half-life. J Clin Pharmacol. 1992; 32: 412-4. [PMID: 1587958]