General Toxicity Notes
Blood levels most often the best guide to therapy. Half-life may be prolonged in heart failure or with reduced hepatic blood flow.
Half-Life (Normalesrd) Hours
8-13/16
Plasma Protein Binding %
70-75
Volume Of Distribution L/Kg
5.5-6.6
Dose For Normal Renal Function
200 mg q8hr
Second Dose
Second Dose: 200-400 mg q8-12h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None [A]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Campbell RW. Mexiletine. N Engl J Med. 1987; 316: 29-34. [PMID: 3537793] / Evers J, Messer W, Aboudan F, Finke K. [Mexiletine in terminal renal failure and various dialysis procedures]. Klin Wochenschr. 1989; 67: 995-8. [PMID: 2615291] / Wang T, Wuellner D, Woosley RL, Stone WJ. Pharmacokinetics and nondialyzability of mexiletine in renal failure. Clin Pharmacol Ther. 1985; 37: 649-53. [PMID: 4006364]