Lidocaine

General Toxicity Notes
Blood levels most often the best guide to therapy. Half-life may be prolonged in heart failure or with reduced hepatic blood flow.
Excreted Unchanged %
10
Half-Life (Normalesrd) Hours
2.0-2.2/1.3-3.0
Plasma Protein Binding %
60-66
Volume Of Distribution L/Kg
1.3-2.2
Dose For Normal Renal Function
50 mg over 2 min, repeat q5min 3
Second Dose
Second Dose: 1-4 mg/min
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,titrate, [B]
References
Bennett PN, Aarons LJ, Bending MR, Steiner JA, Rowland M. Pharmacokinetics of lidocaine and its deethylated metabolite: dose and time dependency studies in man. J Pharmacokinet Biopharm. 1982; 10: 265-81. [PMID: 7175699] / Brierton DG, Mueller BA, Scarim SK, Macias WL. Lidocaine in continuous venovenous hemofiltration [Letter]. Crit Care Med. 1992; 20: 1498-9. [PMID: 1395680]