General Toxicity Notes
Blood pressure is the best guide to dose and interval.
Excreted Unchanged %
15-20
Half-Life (Normalesrd) Hours
2.8-4.2/Unchanged
Plasma Protein Binding %
0
Volume Of Distribution L/Kg
2-3
Dose For Normal Renal Function
5-30 mg bid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, titrate, [D]
References
Halstenson CE, Opsahl JA, Wright CE, Fleishaker JC, Andreadis NA, Sobieraj J, et al. Disposition of minoxidil in patients with various degrees of renal function. J Clin Pharmacol. 1989; 29: 798-802. [PMID: 2808745]
Toxicity Notes
Fluid retention, pericardial effusion.