General Toxicity Notes
Blood pressure is the best guide to dose and interval.
Half-Life (Normalesrd) Hours
2.0-4.5/7-16
Plasma Protein Binding %
87
Volume Of Distribution L/Kg
0.5-0.9
Dose For Normal Renal Function
25-50 mg tid
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q8h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q8h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q8-16h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,titrate, [D]
References
Ludden TM, McNay JL Jr, Shepherd AM, Lin MS. Clinical pharmacokinetics of hydralazine. Clin Pharmacokinet. 1982; 7: 185-205. [PMID: 7047041] / Reece PA. Hydralazine and related compounds: chemistry, metabolism, and mode of action. Med Res Rev. 1981; 1: 73-96. [PMID: 7050561]
Toxicity Notes
Drug-induced lupus erythematosus.