General Toxicity Notes
Blood pressure is the best guide to dose and interval.
Half-Life (Normalesrd) Hours
17-31/30-60
Plasma Protein Binding %
>90
Volume Of Distribution L/Kg
0.2-0.3
Dose For Normal Renal Function
150-300 mg IV bolus
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,titrate, [D]
References
Pearson RM. Pharmacokinetics and response to diazoxide in renal failure. Clin Pharmacokinet. 1977; 2: 198-204. [PMID: 328207]
Toxicity Notes
Sodium and water retention.