General Toxicity Notes
Blood pressure is the best guide to dose and interval. Hyperkalemia in ESRD.
Half-Life (Normalesrd) Hours
2.7/4.0
Plasma Protein Binding %
60
Volume Of Distribution L/Kg
1.7
Dose For Normal Renal Function
10-30 mg bid
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No dose adjustment, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: No dose adjustment, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, titrate, [D]
References
Lowenthal DT, Pitone JM, Affrime MB, Shirk J, Busby P, Kim KE, et al. Timolol kinetics in chronic renal insufficiency. Clin Pharmacol Ther. 1978; 23: 606-15. [PMID: 639436] / Sproat TT, Lopez LM. Around the beta-blockers, one more time. DICP. 1991; 25: 962-71.[PMID: 1683078]