General Toxicity Notes
Blood pressure is the best guide to dose and interval. Hyperkalemia in ESRD.
Half-Life (Normalesrd) Hours
2-6/1-6
Plasma Protein Binding %
81-93
Volume Of Distribution L/Kg
3.7-4.9
Dose For Normal Renal Function
80-160 mg bid
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,titrate, [D]
References
Flouvat B, Decourt S, Potaux L. [Pharmacokinetics of propranolol in patients with chronic renal insufficiency undergoing hemodialysis]. Therapie. 1979; 34: 63-72. [PMID: 483227] / Stone WJ, Walle T. Massive propranolol metabolite retention during maintenance hemodialysis. Clin Pharmacol Ther. 1980; 28: 449-55. [PMID: 7408404] / Wood AJ, Vestal RE, Spannuth CL, Stone WJ, Wilkinson GR, Shand DG. Propranolol disposition in renal failure. Br J Clin Pharmacol. 1980; 10: 561-6. [PMID: 7470370]
Toxicity Notes
Hypoglycemia reported in ESRD. Hyperkalemia in ESRD. Bioavailability may increase in ESRD. Metabolites may cause increased bilirubin by assay interference in ESRD.