General Toxicity Notes
Blood pressure is the best guide to dose and interval. Hyperkalemia in ESRD.
Half-Life (Normalesrd) Hours
2.5-4.0/3-4
Plasma Protein Binding %
50
Volume Of Distribution L/Kg
1.2
Dose For Normal Renal Function
10-40 mg bid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,titrate, [D]
References
Ohnhaus EE, Heidemann H, Meier J, Maurer G. Metabolism of pindolol in patients with renal failure. Eur J Clin Pharmacol. 1982; 22: 423-8. [PMID: 7117354]