General Toxicity Notes
Blood pressure is the best guide to dose and interval. Hyperkalemia in ESRD.
Half-Life (Normalesrd) Hours
3-9/12.9
Plasma Protein Binding %
50
Volume Of Distribution L/Kg
3.3-7.9
Dose For Normal Renal Function
100 mg bid
Second Dose
Second Dose: 200-400 mg bid
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [A]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, titrate, [D]
References
Goa KL, Benfield P, Sorkin EM. Labetalol. A reappraisal of its pharmacology, pharmacokinetics and therapeutic use in hypertension and ischaemic heart disease. Drugs. 1989; 37: 583-627. [PMID: 2663413] / Halstenson CE, Opsahl JA, Pence TV, Luke DR, Sirgo MA, Plachetka JR, et al. The disposition and dynamics of labetalol in patients on dialysis. Clin Pharmacol Ther. 1986; 40: 462-8. [PMID: 3757409] / Wood AJ, Ferry DG, Bailey RR. Elimination kinetics of labetalol in severe renal failure. Br J Clin Pharmacol. 1982; 13: 81S-86S. [PMID: 7093103]
Toxicity Notes
IV use: 20 mg slow injection over a 2-minute period. Additional injections of 40 or 80 mg can be given at 10-minute intervals until a total of 300 mg or continuous infusion of 2 mg/min.