Dilevalol

General Toxicity Notes
Blood pressure is the best guide to dose and interval. Hyperkalemia in ESRD.
Excreted Unchanged %
<5
Half-Life (Normalesrd) Hours
8-12/19-30
Plasma Protein Binding %
75
Volume Of Distribution L/Kg
25
Dose For Normal Renal Function
200-400 mg bid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, titrate, [D]
References
Chrisp P, Goa KL. Dilevalol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in hypertension. Drugs. 1990; 39: 234-63. [PMID: 2184002] / Kelly JG, Laher MS, Donohue J, Doyle GD. The pharmacokinetics of dilevalol in renal impairment. J Hum Hypertens. 1990; 4 Suppl 2: 59-62. [PMID: 2370645]