General Toxicity Notes
Blood pressure is the best guide to dose and interval. Hyperkalemia in ESRD.
Half-Life (Normalesrd) Hours
9-13/18-24
Plasma Protein Binding %
30-35
Volume Of Distribution L/Kg
3
Dose For Normal Renal Function
5 mg q24h
Second Dose
Second Dose: 5-20 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
75% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,titrate, [D]
References
Johns TE, Lopez LM. Bisoprolol: is this just another beta-blocker for hypertension or angina? Ann Pharmacother. 1995; 29: 403-14. [PMID: 7633020] / Kanegae K, Hiroshige K, Suda T, Iwamoto M, Ohta T, Nakashima Y, et al. Pharmacokinetics of bisoprolol and its effect on dialysis refractory hypertension. Int J Artif Organs. 1999; 22: 798-804. [PMID: 10654875] / Lancaster SG, Sorkin EM. Bisoprolol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and angina pectoris. Drugs. 1988; 36: 256-85. [PMID: 2903820]