General Toxicity Notes
Blood pressure is the best guide to dose and interval. Hyperkalemia in ESRD.
Half-Life (Normalesrd) Hours
6-7/15-35
Plasma Protein Binding %
3
Volume Of Distribution L/Kg
1.1
Dose For Normal Renal Function
50-100 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
50-100 mgq24h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
25-50 mgq24h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
25 mg q24h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 25-50 mg after dialysis, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [A]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,titrate, [D]
References
Campese VM, Feinstein EI, Gura V, Mason WD, Massry SG. Pharmacokinetics of atenolol in patients treated with chronic hemodialysis or peritoneal dialysis. J Clin Pharmacol. 1985; 25: 393-5. [PMID: 4031118] / Flouvat B, Decourt S, Aubert P, Potaux L, Domart M, Goupil A, et al. Pharmaco-kinetics of atenolol in patients with terminal renal failure and influence of haemodialysis. Br J Clin Pharmacol. 1980; 9: 379-85. [PMID: 7378254] / Salahudeen AK, Wilkinson R, McAinsh J, Bateman DN. Atenolol pharmacokinetics in patients on continuous ambulatory peritoneal dialysis. Br J Clin Pharmacol. 1984; 18: 457-60. [PMID: 6487486] / Sassard J, Pozet N, McAinsh J, Legheand J, Zech P. Pharmacokinetics of atenolol in patients with renal impairment. Eur J Clin Pharmacol. 1977; 12: 175-80. [PMID: 590303] / Wadworth AN, Murdoch D, Brogden RN. Atenolol. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders. Drugs. 1991; 42: 468-510. [PMID: 1720383]
Toxicity Notes
Accumulates in ESRD.