General Toxicity Notes
Blood pressure is the best guide to dose and interval. Hypotensive effects magnified by natriuretic agents or sodium depletion. May cause hyperkalemia, metabolic acidosis. Acute renal dysfunction with bilateral or transplant renal artery stenosis, low renal perfusion pressure. Dry cough in 5-10% of patients.
Excreted Unchanged %
80-90
Half-Life (Normalesrd) Hours
2-3/10-14
Plasma Protein Binding %
60
Volume Of Distribution L/Kg
0.8
Dose For Normal Renal Function
125 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50-75% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data
Supplement For Dialysis [Recommendation Level]: Pd
PD: No dat
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, titrate, [D]
References
Rakhit A, Radensky P, Szerlip HM, Kochak GM, Audet PR, Hurley ME, et al. Effect of renal impairment on disposition of pentopril and its active metabolite. Clin Pharmacol Ther. 1988; 44: 39-48. [PMID: 3391004]