General Toxicity Notes
Blood pressure is the best guide to dose and interval. Hypotensive effects magnified by natriuretic agents or sodium depletion. May cause hyperkalemia, metabolic acidosis. Acute renal dysfunction with bilateral or transplant renal artery stenosis, low renal perfusion pressure. Dry cough in 5-10% of patients.
Half-Life (Normalesrd) Hours
10-11/30
Plasma Protein Binding %
96
Volume Of Distribution L/Kg
0.15
Dose For Normal Renal Function
10 mg q24h
Second Dose
Second Dose: 10-40 mg q12-24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50-75% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
25-50% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,titrate, [D]
References
Balfour JA, Goa KL. Benazepril. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and congestive heart failure. Drugs. 1991; 42: 511-39. [PMID: 1720384] / Shionoiri H, Ueda S, Minamisawa K, Minamisawa M, Takasaki I, Sugimoto K, et al. Pharmacokinetics and pharmacodynamics of benazepril in hypertensive patients with normal and impaired renal function. J Cardiovasc Pharmacol. 1992; 20: 348-57. [PMID: 1279278]