General Toxicity Notes
Blood pressure is the best guide to dose and interval.
Excreted Unchanged %
20-30
Half-Life (Normalesrd) Hours
9-12/8-12
Plasma Protein Binding %
90-94
Volume Of Distribution L/Kg
0.5-0.9
Dose For Normal Renal Function
1 mg hs
Second Dose
Second Dose: 1-20 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Achari R, Laddu A. Terazosin: a new alpha adrenoceptor blocking drug. J Clin Pharmacol. 1992; 32: 520-3. [PMID: 1353083] / Titmarsh S, Monk JP. Terazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in essential hypertension. Drugs. 1987; 33: 461-77. [PMID: 2885169]
Toxicity Notes
Similar to prazosin (q.v.).