Reserpine

General Toxicity Notes
Blood pressure is the best guide to dose and interval.
Excreted Unchanged %
<1
Half-Life (Normalesrd) Hours
46-168/87-323
Plasma Protein Binding %
96
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
0.05-0.25 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Zsot&#233; r TT, Johnson GE, DeVeber GA, Paul H. Excretion and metabolism of reserpine in renal failure. Clin Pharmacol Ther. 1973; 14: 325-30. [PMID: 4698561]
Toxicity Notes
Excessive sedation. Gastrointestinal bleeding.