Prazosin

General Toxicity Notes
Blood pressure is the best guide to dose and interval.
Excreted Unchanged %
<5
Half-Life (Normalesrd) Hours
2-3/3.6
Plasma Protein Binding %
97
Volume Of Distribution L/Kg
1.2-1.5
Dose For Normal Renal Function
1-15 mg bid-tid
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Lameire N, Gordts J. A pharmacokinetic study of prazosin in patients with varying degrees of chronic renal failure. Eur J Clin Pharmacol. 1986; 31: 333-7. [PMID: 3792430] / Seyffart G. Drug Dosage in Renal Insufficiency. Dordrecht, The Netherlands: Kluwer Academic; 1991. / Vincent J, Meredith PA, Reid JL, Elliott HL, Rubin PC. Clinical pharmacokinetics of prazosin&#151; 1985. Clin Pharmacokinet. 1985; 10: 144-54. [PMID: 3888489]
Toxicity Notes
May produce profound first-dose hypotension. Titration of renal patients should begin from low doses.