General Toxicity Notes
Blood pressure is the best guide to dose and interval.
Excreted Unchanged %
25-40
Half-Life (Normalesrd) Hours
1.5-6.0/6-16
Plasma Protein Binding %
<15
Volume Of Distribution L/Kg
0.5
Dose For Normal Renal Function
250-500 mg q8h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q8h [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q8-12h [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q12-24h [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, titrate, [D]
References
Myhre E, Rugstad HE, Hansen T. Clinical pharmacokinetics of methyldopa. Clin Pharmacokinet. 1982; 7: 221-33. [PMID: 7047042] / Seyffart G. Drug Dosage in Renal Insufficiency. Dordrecht, The Netherlands: Kluwer Academic; 1991. / Yeh BK, Dayton PG, Waters WC 3rd. Removal of alpha-methyldopa (aldomet) in man by dialysis. Proc Soc Exp Biol Med. 1970; 135: 840-3. [PMID: 5486722]
Toxicity Notes
Orthostatic hypotension, retroperitoneal fibrosis. Elevates serum creatinine by acting as a chromogen. Active metabolites with long half-life.