General Toxicity Notes
Blood pressure is the best guide to dose and interval.
Half-Life (Normalesrd) Hours
14-19/25-35
Plasma Protein Binding %
95
Volume Of Distribution L/Kg
3-6
Dose For Normal Renal Function
40 mg bid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50
References
Ebihara A, Fujimura A. Metabolites of antihypertensive drugs. An updated review of their clinical pharmacokinetic and therapeutic implications. Clin Pharmacokinet. 1991; 21: 331-43. [PMID: 1773548] / Persson B, Heykants J, Hedner T. Clinical pharmacokinetics of ketanserin. Clin Pharmacokinet. 1991; 20: 263-79. [PMID: 2036747]
Toxicity Notes
Serotonin receptor antagonist. Protein binding decreased in uremia.