General Toxicity Notes
Blood pressure is the best guide to dose and interval.
Half-Life (Normalesrd) Hours
10-30/15-25
Plasma Protein Binding %
70
Volume Of Distribution L/Kg
6.3
Dose For Normal Renal Function
1-2 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [A]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Carchman SH, Crowe JT Jr, Wright GJ. The bioavailability and pharmacokinetics of guanfacine after oral and intravenous administration to healthy volunteers. J Clin Pharmacol. 1987; 27: 762-7. [PMID: 3323255] / Carchman SH, Sica DA, Davis J, Crowe JT Jr, Wasserman AJ, Proctor JD, et al. Steady-state plasma levels and pharmacokinetics of guanfacine in patients with renal insufficiency. Nephron. 1989; 53: 18-23. [PMID: 2674741] / Kiechel JR. Pharmacokinetics of guanfacine in patients with impaired renal function and in some elderly patients. Am J Cardiol. 1986; 57: 18E-21E. [PMID: 3513525] / Kirch W, Kohler H, Axthelm T. Pharmacokinetics of guanfacine in patients undergoing haemodialysis. Eur J Drug Metab Pharmacokinet. 1982; 7: 277-80. [PMID: 6762301] / Sorkin EM, Heel RC. Guanfacine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension. Drugs. 1986; 31: 301-36. [PMID: 3519177]
Toxicity Notes
Similar to clonidine, but milder.