General Toxicity Notes
Blood pressure is the best guide to dose and interval.
Excreted Unchanged %
25-50
Half-Life (Normalesrd) Hours
120-140/No data
Plasma Protein Binding %
<5
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
10-100 mg q24h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q24h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q24h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q24-36h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data
Supplement For Dialysis [Recommendation Level]: Pd
PD: No dat
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
Toxicity Notes
Tricyclic antidepressants decrease efficacy. Orthostatic hypotension, diarrhea.