General Toxicity Notes
Blood pressure is the best guide to dose and interval.
Excreted Unchanged %
30-40
Half-Life (Normalesrd) Hours
4-10/19
Plasma Protein Binding %
20
Volume Of Distribution L/Kg
11.5
Dose For Normal Renal Function
10-50 mg bid
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q12h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q12-24h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q24-48h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Finnerty FA Jr, Brogden RN. Guanadrel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in hypertension. Drugs. 1985; 30: 22-31. [PMID: 3896742] / Halstenson CE, Opsahl JA, Abraham PA, Schwenk MH, Andreadis NA, Antal EJ, et al. Disposition of guanadrel in subjects with normal and impaired renal function. J Clin Pharmacol. 1989; 29: 128-32. [PMID: 2715368]
Toxicity Notes
Similar to guanethidine, but less diarrhea.