Guanabenz

General Toxicity Notes
Blood pressure is the best guide to dose and interval.
Excreted Unchanged %
<5
Half-Life (Normalesrd) Hours
12-14/No data
Plasma Protein Binding %
90
Volume Of Distribution L/Kg
10-12
Dose For Normal Renal Function
2-4 mg bid
Second Dose
Second Dose: 8-16 mg bid
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Gehr M, MacCarthy EP, Goldberg M. Guanabenz: a centrally acting, natriuretic antihypertensive drug. Kidney Int. 1986; 29: 1203-8. [PMID: 3528613] / Holmes B, Brogden RN, Heel RC, Speight TM, Avery GS. Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension. Drugs. 1983; 26: 212-29. [PMID: 6352237]
Toxicity Notes
Similar to clonidine.