General Toxicity Notes
Blood pressure is the best guide to dose and interval.
Half-Life (Normalesrd) Hours
16-22/16-22
Plasma Protein Binding %
98
Volume Of Distribution L/Kg
1.0-1.7
Dose For Normal Renal Function
1-16 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [A]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Carlson RV, Bailey RR, Begg EJ, Cowlishaw MG, Sharman JR. Pharmacokinetics and effect on blood pressure of doxazosin in normal subjects and patients with renal failure. Clin Pharmacol Ther. 1986; 40: 561-6. [PMID: 2945688] / Fulton B, Wagstaff AJ, Sorkin EM. Doxazosin. An update of its clinical pharmacology and therapeutic applications in hypertension and benign prostatic hyperplasia. Drugs. 1995; 49: 295-320. [PMID: 7537194] / Oliver RM, Upward JW, Dewhurst AG, Honeywell R, Renwick AG, Waller DG. The pharmacokinetics of doxazosin in patients with hypertension and renal impairment. Br J Clin Pharmacol. 1990; 29: 417-22. [PMID: 2139337]
Toxicity Notes
May produce profound first-dose hypotension. Titration of renal patients should begin from low doses.