Acetaminophen

Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
2/2
Plasma Protein Binding %
20-30
Volume Of Distribution L/Kg
1-2
Dose For Normal Renal Function
650 mg q4h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q4h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q6h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q8h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,[B]
References
Agarwal R, Farber MO. Is continuous veno-venous hemofiltration for acetaminophen-induced acute liver and renal failure worthwhile? Clin Nephrol. 2002; 57: 167-70. [PMID: 11863129] / Blantz RC. Acetaminophen: acute and chronic effects on renal function. Am J Kidney Dis. 1996; 28: S3-6. [PMID: 8669426] / Clissold SP. Paracetamol and phenacetin. Drugs. 1986; 32 Suppl 4: 46-59. [PMID: 3552585] / D&#146; Arcy PF. Paracetamol. Adverse Drug React Toxicol Rev. 1997; 16: 9-14. [PMID: 9192054] / Segasothy M, Suleiman AB, Puvaneswary M, Rohana A. Paracetamol: a cause for analgesic nephropathy and end-stage renal disease. Nephron. 1988; 50: 50-4. [PMID: 3050572]
Toxicity Notes
Overdose may be nephrotoxic. Drug is major metabolite of phenacetin.