Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
2-5/Unchanged
Plasma Protein Binding %
92
Volume Of Distribution L/Kg
2-3
Dose For Normal Renal Function
Anesthetic induction (individualized)
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50,titrate, [D]
References
Davis PJ, Stiller RL, Cook DR, Brandom BW, Davin-Robinson KA. Pharmacokinetics of sufentanil in adolescent patients with chronic renal failure. Anesth Analg. 1988; 67: 268-71. [PMID: 2964213] / Fyman PN, Reynolds JR, Moser F, Avitable M, Casthely PA, Butt K. Pharmacokinetics of sufentanil in patients undergoing renal transplantation. Can J Anaesth. 1988; 35: 312-5. [PMID: 2968186] / Wiggum DC, Cork RC, Weldon ST, Gandolfi AJ, Perry DS. Postoperative respiratory depression and elevated sufentanil levels in a patient with chronic renal failure. Anesthesiology. 1985; 63: 708-10. [PMID: 2932984]