Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
9-15/12-20
Plasma Protein Binding %
78
Volume Of Distribution L/Kg
16
Dose For Normal Renal Function
65 mg PO q6-8h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Avoid
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Avoid, [D]
References
Colburn WA, Inturrisi CE. D-Propoxyphene: accumulation or altered kinetics? [Letter]. Eur J Clin Pharmacol. 1985; 28: 725-6. [PMID: 4065198]
Toxicity Notes
Active metabolite norpropoxyphene accumulates in ESRD.