Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
2-5/No data
Plasma Protein Binding %
50-75
Volume Of Distribution L/Kg
5
Dose For Normal Renal Function
50 mg q4h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
75% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [D]
References
Forycki Z, Martens F, Thalhofer S, Ibe K. Tranquilizers, analgetics and antidepressants in patients treated with hemodialysis. Blood Purif. 1985; 3: 109-19. [PMID: 2869770] / Mather LE. Opioid pharmacokinetics in relation to their effects. Anaesth Intensive Care. 1987; 15: 15-22. [PMID: 2882700] / Yeh SY, Todd GD, Johnson RE, Gorodetzky CW, Lange WR. The pharmacokinetics of pentazocine and tripelennamine. Clin Pharmacol Ther. 1986; 39: 669-76. [PMID: 3709032]