Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
1.0-1.5/No data
Plasma Protein Binding %
54
Volume Of Distribution L/Kg
3
Dose For Normal Renal Function
2 mg IV
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Bowden CA, Krenzelok EP. Clinical applications of commonly used contemporary antidotes. A US perspective. Drug Saf. 1997; 16: 9-47. [PMID: 9010641] / Cherny NI. Opioid analgesics: comparative features and prescribing guidelines. Drugs. 1996; 51: 713-37. [PMID: 8861543]