Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
1-3/No data
Plasma Protein Binding %
88-95
Volume Of Distribution L/Kg
0.3-1
Dose For Normal Renal Function
Anesthetic induction 8-40 µg/kg
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, titrate, [D]
References
Chauvin M, Lebrault C, Levron JC, Duvaldestin P. Pharmacokinetics of alfentanil in chronic renal failure. Anesth Analg. 1987; 66: 53-6. [PMID: 3099599] / Mather LE. Opioid pharmacokinetics in relation to their effects. Anaesth Intensive Care. 1987; 15: 15-22. [PMID: 2882700] / Meistelman C, Saint-Maurice C, Lepaul M, Levron JC, Loose JP, Mac Gee K. A comparison of alfentanil pharmacokinetics in children and adults. Anesthesiology. 1987; 66: 13-6. [PMID: 3099603] / Persson MP, Nilsson A, Hartvig P. Pharmacokinetics of alfentanil in total i.v. anaesthesia. Br J Anaesth. 1988; 60: 755-61. [PMID: 3134933] / Scholz J, Steinfath M, Schulz M. Clinical pharmacokinetics of alfentanil, fentanyl and sufentanil. An update. Clin Pharmacokinet. 1996; 31: 275-92. [PMID: 8896944] / Sitar DS, Duke PC, Benthuysen JL, Sanford TJ, Smith NT. Aging and alfentanil disposition in healthy volunteers and surgical patients. Can J Anaesth. 1989; 36: 149-54. [PMID: 2495860] / Stanski DR. Narcotic pharmacokinetics and dynamics: the basis of infusion applications. Anaesth Intensive Care. 1987; 15: 23-6. [PMID: 2882701] / Van Peer A, Levron JC, Noorduin H, Heykants J. Overview of the clinical pharmacokinetics of alfentanil. Acta Anaesthesiol Belg. 1984; 35 Suppl: 261-3. [PMID: 6440399] / Van Peer A, Vercauteren M, Noorduin H, Woestenborghs R, Heykants J. Alfentanil kinetics in renal insufficiency. Eur J Clin Pharmacol. 1986; 30: 245-7. [PMID: 3086106] / Waud BE, Waud DR. Dose-response curves and pharmacokinetics. Anesthesiology. 1986; 65: 355-8. [PMID: 3094406]